Herbal medication having therapeutic and healing effects is referred to as phytomedicine. Phytomedicines are still the most common initial point for the production of such substances, which could be used as clinically relevant and fascinating molecules in the future. Phytomedicines (plant-derived pharmaceuticals) exhibit a wide range of biological actions, and as a result, phytomedicines have been used to prevent and treat diseases all over the world since ancient times. However, insolubility, hydrophobicity, low bioavailability, and high toxicity are among the chemical and biological hurdles that limit the use of such critical phytomedicines. Drug-delivery methods have garnered a lot of interest in this regard. It has existed from the beginning of human society. If phytomedicine is merged with other medical sciences in a wider interdisciplinary approach, it may prove to be a revolutionary step in the current health-care scenario.