Title : Effects of cycloastragenol on a mouse model of asthma and airway organoids
Abstract:
Asthma is characterized by airway inflammation and epithelial barrier dysfunction, leading to increased permeability and susceptibility to allergens. This study aimed to evaluate the effects of Cycloastragenol (CAG), a key metabolite of Astragalus membranaceus, on airway epithelial barrier function in mouse and organoid models. Mice were treated with CAG and assessed for airway inflammation and barrier integrity, while organoids were exposed to CAG, and tight junction protein expression was analyzed. Results showed that CAG significantly reduced airway inflammation in mice. In mice, CAG enhanced epithelialbarrier integrity by increasing tight junction protein levels. In airway organoids, CAG significantly reduced epithelial barrier permeability. These findings suggest that CAG may improve airway epithelial barrier and offer potential therapeutic benefits for asthma treatment.
