Title : Unlocking healing potentials: Utilizing traditional chinese medicine formulation for alleviating osteoporosis symptoms
Abstract:
Population aging is a significant global concern, with osteoporosis emerging as a prevalent epidemic worldwide. Bone remodeling occurs within the body and involves the formation and growth of new bone tissue. In contrast, some existing bone tissue is absorbed and removed—a process regulated primarily by osteoblasts and osteoclasts. This study evaluates a randomized clinical trial (RCT) of traditional Chinese medicine formulation (TCMF) and the activity and mechanisms of TCMF using the zebrafish model. A 12- week randomized clinical trial (RCT) was conducted to assess the efficacy of TCMF in osteoporosis patients, employing various indices, including Bath Ankylosing Spondylitis indices, WHOQOL-BREF Taiwan, and Oswestry Disability Index. The RCT and gene pharmacology research results indicate that TCMF exhibits significant benefits, particularly in patients younger than 65 and those with a BMI <25. Furthermore, we conducted an activity and chemical molecular network strategy to explore the relationship between TCMF metabolites and in vivo activity. To investigate further, independent component analyses were conducted, aiming to identify key active ingredients for the future development of qualitative and quantitative analysis methods to establish quality control references.
Audience Take Away Notes:
- Randomized clinical trial (RCT) of traditional Chinese medicine formulations (TCMF)
- Chemical molecular network
- In vivo zebrafish model
