Most of the world’s population suffers from at least one chronic disease, and one-third has more than one. Predictably, this leads to pain, suffering and high health care costs. While pharmaceutical drugs have reduced suffering and saved many lives, they can also be expensive, produce side effects and lead to resistance. Other treatment approaches that reduce these negative consequences would therefore provide major health care benefit. Healthy diet is one such option. We have developed an innovative therapeutic strategy for treating various health conditions called Dietary Rational Gene Targeting that uses healthy dietary agents such as blueberries, olive oil and green tea to modulate the expression of key genes involved in a wide range of diseases back toward the normal. Dietary Rational Gene Targeting is an extension of nutrigenomic studies offering numerous advantages over pharmaceutical drug treatment including significantly lower cost, heathier treatment, and easy application requiring only simple dietary modification. Most recently, we have considered this from an anti-inflammatory perspective since inflammation is a major driver of mortality. For example, targeting key proinflammatory gene products such as TNFα is one strategy to treat autoimmune diseases, and the basis of medical drugs such as Adalimumab and Etanercept. Targeting this and other inflammation-associated molecules with healthy diet, healthy dietary extracts, or select phytochemicals provides complementary and/or alternative options to treat these medical conditions. Identification of such anti-inflammation (and other) genes and their modulation with diet was achieved through our Eat4Genes app build and based on data from extensive Bioinformatic mining of public databases (e.g., GEO and PubMed). Our combined Dietary Rational Gene Targeting strategy and Eat4Genes app provide an innovative and publicly-available option for patients, healthcare providers and researchers to treat and prevent numerous health conditions including autoimmune disease, a main focus of this presentation.
Audience Take Away Notes:
- This presentation will provide a new natural therapy perspective for the audience toward educating them about a new benefit of healthy diet.
- This represents a new type of translational approach that students, patients, community, medical providers and researchers can use for education and dietary suggestion purposes.
- This presentation will also emphasize the use of our dietary strategy to treat inflammation-related disorders, in part because inflammation is associated with numerous medical conditions including most leading causes of death in parts of the world.