Liver diseases can affect almost every age group, and their incidence is increasing worldwide due to the extensive spread of hepatitis and the western lifestyle. The primary cause of liver disease includes infection, exposure to drugs/toxic compounds, diet and alcohol, which further contribute to inflammation, fibrosis and even liver cancer. Traditional medicines sought and encompassed a wide range of approaches. They came to practice during the ancient Vedic period and have a long-lasting curative effect, easy availability, a natural way of healing, and negligible side effects. Traditional medicines are gaining importance throughout the world in clinical practice. Natural products are prepared from plant extracts, herbs, fruits, and vegetables and have been used conventionally for treating liver diseases. Various medicinal plants/natural products such as Picrorhiza kurroa, Swertia sp., curcumin, etc., have a potential chemoprotective and hepatoprotective effect against common liver diseases. The limitation of applications of natural products as medicines comes from the lack of scientific studies that could provide actual proof of the efficacy of these products. Thus, anecdotal success and personal experience are the often-driving forces for accepting these traditional medicines among the clinical population. Our group is focused on validating the efficacy of natural/traditional drugs in experimental models.
Audience Take Away Notes:
- The audience can learn about the various natural products/traditional drugs having potential hepatorpotective activity
- The presentation will explain the various preclinical animal models used to validate the efficacy of drugs.
- Focus will be on to explain the molecular mechanism of action of different products based on our studies.