HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

8th Edition of International Conference on

Traditional Medicine, Ethnomedicine and Natural Therapies

June 05-07, 2025 | Rome, Italy

Traditional Medicine 2023

Is a widely used herbal remedy, Maytenus Senegalensis, safe for Malaria treatment? Study finds promising results.

Speaker at Traditional Medicine, Ethnomedicine and Natural Therapies 2023 - Kamaka Kassimu
Ifakara Health Institute, Tanzania, United Republic of
Title : Is a widely used herbal remedy, Maytenus Senegalensis, safe for Malaria treatment? Study finds promising results.

Abstract:

This presentation will discuss the results of a study aimed at evaluating the safety and tolerability of M. senegalensis, a medicinal plant widely used in traditional African medicine for treating infectious and inflammatory diseases. The study design was an open-label, single-arm, dose-escalation that enrolled twelve healthy Tanzanian males aged 18 to 45 years, divided into four study dose groups. Volunteers were administered M.senegalensis in various doses (G1: 400mg once, G2: 600mg, G3& G4: 800mg 8 hourly for four days), and their safety and tolerability were monitored through various medical evaluations on days 0 to 7, 14, and 56 post-administrations. The results showed that there were no deaths or serious adverse events in any of the study groups, and no adverse events that led to premature discontinuation. Although there were significant mean changes observed in laboratory parameters, such as WBC, Neutrophils, Lymphocytes, Eosinophils, Alanine aminotransferase, Creatinine, and Total bilirubin, these changes were not associated with any signs of toxicity or clinical symptoms. Furthermore, the study concluded that M. senegalensis was safe and tolerable when administered at a dose of 800mg 8 hourly for four days. The presentation will cover the background of the study, including the use of M. senegalensis in traditional African medicine and the need to establish its safety and tolerability through scientific evidence. The study design, methodology, and results will be discussed in detail, including the safety evaluations conducted and the laboratory parameters measured. Additionally, the presentation will highlight the significance of the study's findings and the potential for adapting the study design to evaluate other herbal remedies. The audience will learn about the safety and tolerability of M. senegalensis, which has been traditionally used in African medicine for centuries. The presentation will provide scientific evidence of the safety and tolerability of the herbal remedy, which can inform the development of new treatments for infectious and inflammatory diseases. Additionally, the study design can be adapted to evaluate the safety of other herbal remedies. This research can benefit researchers, clinicians, and policymakers who are interested in exploring the safety and efficacy of herbal remedies for treating various diseases. The study's findings can inform the development of new treatments for infectious and inflammatory diseases, and the study design can be used to evaluate the safety and tolerability of other herbal remedies. Overall, the presentation provides valuable insights into the safety and tolerability of M. senegalensis and its potential for use in modern medicine.

Audience Take Away Notes:

  • The safety and tolerability of M. Senegalensis as a medicinal plant for the treatment of infectious and inflammatory diseases in Africa.
  • The study design and methodology for evaluating the safety and tolerability of herbal remedies.
  • The laboratory parameters used to assess the safety and tolerability of herbal remedies.

Biography:

Kamaka Kassimu is a highly motivated research scientist employed by the Ifakara Health Institute. He has been working at the Bagamoyo Clinical Trials Facility for the last 10 years, and has an international track record of success. He is skilled in applying clinical research regulatory requirements in the evaluation of  investigational products in clinical research, including herbal products. Currently, Kamaka Kassimu is a PhD candidate in Research and Publications in the Department of Parasitology at the School of Public Health, Muhimbili University of Health and Allied Sciences in Dar es Salaam, Tanzania. He has published more than 18 research articles in scientific journals.

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