Title : Propolis Effects of Mount Lawu Central of Java Indonesia as Anti Reactive Oxygen Species ROS Anti Inflammation Inhibits Fibrosis Prevents Target Organ Damage and Multi Organ Dysfunction MOD
The problem of increased ROS infection, inflammation, target organ damage, Multi-Organ Dysfunction (MOD) are the important problem in Indonesia. ROS make damage Kappa Beta Inhibitors (IKB) because of IKB does not optimally inhibit Nuclear Factor Kappa Beta (NFKB). As a result, hyperexpression of NFKB causes an increase in pro-inflammatory cytokines and growth factors. Pro-inflammatory cytokines such as Tumor necrosis factor-alpha (TNF-α), IL-6, IL-8, and IL-17. Growth factor, in particular, alters Growth Factor Beta 1 (TGFβ1), TNF-α stimulates endothelium express E-selectin to attract Polymorphonuclear (PMN), then PMN expresses ROS, lysozyme, and matrix metalloproteinase. IL-8, IL-17 also attract PMN so that the number of PMN increases. ROS and Lysozyme cause necrosis of target organ cells. ROS damage DNA causing apoptosis. IL-6 stimulates hepatocytes express CRP causing endothelial dysfunction, eventually increasing ROS expression. TGFβ1 stimulates fibroblasts to express extracellular matrix including collagen causing fibrosis. Propolis contains polyphenols and flavonoids which are anti-ROS, resulting in apoptosis, necrosis, fibrosis, target organ damage, and inhibited MOD. Target organs include rhinosinusitis, otitis media, and organ damage (liver, kidney, blood vessels, and skin). The research method of these various organs. Post-test only control group design on white rats. The conclusion various studies proves the role Propolis in inhibiting target organ damage complementary therapy its effectiveness is better than standard therapy alone. Propolis is a pearl of local wisdom that is expected to increase community participation in overcoming diseases and improve socioeconomic conditions.