HYBRID EVENT: You can participate in person at Tokyo, Japan or Virtually from your home or work.

5th Edition of International Conference on

Traditional Medicine, Ethnomedicine and Natural Therapies

May 22-23, 2023 | Tokyo, Japan

Traditional Medicine 2022

Bilkisu Adedoyin

Speaker at Traditional Medicine, Ethnomedicine and Natural Therapies 2022 - Bilkisu Adedoyin
University of Abuja, Nigeria
Title : In vitro cytotoxicity of Euphorbia heterophylla against human cancer cell lines

Abstract:

Euphorbia heterophylla (EH) is a well-known Africa medicinal plant, which has been used in the African traditional medicine for the treatment of various human ailments including tumours and cancers. Previous phytochemical screening of E. hetrophylla has detected many flavonoids, terpenoids and sterols (Okeniyi et al., 2012: Silva et al., 2019). Seven compounds were isolated from the different fractions of EH including three biflavonoids (Cupressuflavone, Quecertin and Quercitrin) and four diterpenes (13-epicupressic acid, imbricatholic acid, 3α-hydroxy sandaracopimaric acid and β− hydroxysandaracopimaric acid). All the compounds were tested for their cytotoxicity against the A549 cell lines and compared with the anticancer standard etoposide. Cupressuflavone and 13-epicupressic acid showed the highest cytotoxicity against human lung cancer cells lines (A549) with IC50 values of 58 and 73µM respectively. The current findings support the traditional use of EH for the treatment of tumours and other cancer related diseases. It is suggested that the cytotoxic activity revealed in the polar MeOH fractions was due to the presence of cytotoxic bioflavonoids and the cytotoxicity observed with the non-polar fractions of E. heterophylla root were contributed by various cytotoxic terpenes.

Biography:

Dr.  Bilkisu studied Chemistry at   Ahmadu Bello University, Nigeria, Obtained M Sc in and graduated as  MSc in 2013. She then joined the research group of  Prof. Satyajit  Sarker at the  Centre for Natural Products Discovery, School of Pharmacy and Biomolecular  Science of Liverpool John Moores University, United Kingdom. She received her PhD degree in 2018 from Usmanu Danfodiyo University and LJMU  as a split collaborative research programme between the two institutions. She is presently a  lecturer at the University of Abuja. After one year postdoctoral fellowship supervised by  Prof M. S Abubakar at the Centre for venom and toxin and drug development, Nigeria.  She has published more than 10 research articles in international journals.

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