Abstract
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A 90-day randomized, placebo-controlled intervention study was conducted to examine the differences in body morphology, metabolic indicators, liver and kidney function and thyroid function of 60 overweight and obese people after 1 month and 3 months of intervention with one capsule daily containing 1.5 × 10¹ TFU pasteurized Akkermansia muciniphila 001 postbiotic (AKK001™) and an undisclosed amount of amount of butyrate (tributyrin), compared with the placebo-control group. Results were that one and three months after intervention, the intervention group showed statistically significant differences (P<0.05) compared to the control group in weight, body fat percentage, BMI, waist circumference, hip circumference, abdominal subcutaneous fat thickness, abdominal visceral fat thickness, glucose, total cholesterol, triglycerides, HDL-cholesterol, LDL- cholesterol, and insulin, as well as ALT, AST, total bilirubin, creatinine and urea nitrogen, thyroid-stimulating hormone, free triiodothyronine and free thyroxine. In conclusion, a pasteurized Akkermansia muciniphila 001 postbiotic product was effective for improving anthropometric measures, body morphology, metabolic indicators as well as liver, kidney and thyroid function.
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