Title : Screening of ethanolic tibbe, unani and traditional herbs extracts for antineoplastic activity on cancer cell lines
Abstract:
Background: As per the Indian Council of Medical Research (ICMR) the total number of cancer cases is expected to be nearly 17.3 lakh by 2020. Considering this, the bulk of treating cancer patients with surgery, chemotherapy, and radiation is significantly high. Out of these three mainstay treatments, it is difficult to enumerate the prevalence of patients undergoing cancer surgeries with a curative intent or to debulk the disease as a palliative measure following which adjuvant chemotherapeutical measures certainly follows the treatment protocol.
Objective: There is a constant search for novel medications to either curb the disease or to keep the disease under control with good quality of life of the patient post Oncological surgeries.
Methods: Keeping this view, Ethanol-botanical sources of Tib-E-Nabvi, Unani, Ayurveda & Folk Medicine were explored and in vitro studies on 20cancer cell lines and on patients’ biopsies were carried out by dividing the ethanolic herbal extract along with approved drugs into 5 study groups.
Results: All plant extracts exhibited dose- and time-dependent killing capabilities in various human-derived tumor cell lines and primary cultures established from patients’ biopsies.Results from cell counting showed that the compound, at all the doses tested, inhibited the proliferation of cells in vitro
Conclusion: The ethanolic extracts of these groups of herbal medications in different doses can be antineoplastic as well as chemotherapeutical adjuvants for different cancer treatments especially post-cancer surgeries.
