HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.

6th Edition of International Conference on

Traditional Medicine, Ethnomedicine and Natural Therapies

June 20-22, 2024 | Paris, France

Traditional Medicine 2024

Ayman S Ibrahim

Speaker at Traditional Medicine, Ethnomedicine and Natural Therapies 2024 - Ayman S Ibrahim
Daba Lab Consultant, United States
Title : Exploring the anti-cancer potential of polysaccharides isolated from higher basidiomycetes mushrooms: A comprehensive review

Abstract:

Cancer remains a significant global health concern, prompting extensive research into novel therapeutic strategies. This review focuses on the anti-cancer effects of polysaccharides extracted from higher basidiomycetes mushrooms, particularly their potential in inhibiting tumor growth and metastasis. The research, conducted at the Division of Medical Biochemistry, Molecular Biology Laboratory, Faculty of Health Sciences, University of Cape Town, South Africa, has investigated the anti-tumor activity of these polysaccharide extracts across various cancer cell lines. The study reveals the potent anti-tumor activity of the polysaccharides against sarcoma 180, mammary adenocarcinoma 755, leukemia L-1210, and other tumor types. The primary mechanism underlying this anti-cancer effect is attributed to an indirect host-mediated immunotherapeutic response. Ongoing studies in various laboratories continue to explore the immunopotentiator role of these polysaccharides, sparking intense debates within the scientific community. This review provides a comprehensive summary of the current research status in the field, highlighting the significance of mushroom-derived polysaccharides, such as lentinan, schizophyllan, and maitake, in inducing apoptosis and inhibiting metastasis. The global urgency to address cancer as a leading cause of mortality has prompted a broad spectrum of investigations, including the use of chemical agents like non-steroid anti-inflammatory drugs (NSAIDs) to minimize carcinogenic risks. The presented information underscores the potential of mushroom polysaccharides as a promising avenue in the development of anti-cancer therapies. Further exploration of their immunotherapeutic properties may contribute valuable insights to the ongoing battle against cancer, offering new perspectives on prevention and treatment strategies.

Biography:

Dr. Ayman Daba Ibrahim, originally from Egypt and currently residing in the Chicago area, is a Lab Consultant, a chartered chemist, and a member of the Royal Society of London. He graduated from the University of Ain Shames with a degree in biochemistry, and his academic journey includes a master's and doctorate focusing on the medicinal values of mushrooms for anticancer purposes. Awarded a fellowship by the International Union Against Cancer, he conducted postdoctoral research in Aarhus Kommune Hospital and received a Fulbright Scholarship at Wisconsin Lacrosse and Roswell Park Cancer Hospital. With a rich background, he now seeks to share his knowledge globally.

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