Dyslipidemia is a lipoprotein metabolism disorder that has been directly linked to hyperglycemia, insulin resistance and cardiovascular disease. Psammomys obesus (P. obesus) is a naturally insulin-resistant animal that exhibits a tendency to develop diet-induced hyperglycemia and obesity. We hypothesized that a palm oil-enriched diet (PD) might prevent hyperglycemia and contribute to cav-1 overexpression and reactive oxygen species (ROS) production in P. obesus. Our study was designed to compare the effects of a palm oil-enriched diet with those of a standard diet (SD) on glucose and lipid metabolism, body weight gain and endothelial caveolin-1 (cav-1) protein expression in P. obesus. After 12 weeks of feeding with either the PD or SD, we observed that the PD caused a marked increase in lipid parameters, even in normoglycemic P. obesus. The PD group displayed significantly higher levels of total cholesterol (C), LDL-C, triglycerides (TG) and body weight gain than the SD group. Cav-1β protein expression and ROS production were increased in the vascular endothelium of PD-treated P. obesus.
The results of our experimental study suggest that the PD exerts deleterious effects on the vascular system that are accompanied by pronounced dyslipidemia in normoglycemic P. obesus which may lead to cav-1β protein overexpression and ROS production in the vascular wall.
Dr. Mohamed El Fadel OUSMAAL is Researcher at the biology and animal physiology laboratory of Higher Normal School of Kouba - Algiers, and associate professor at Nature and life sciences department, Faculty of Sciences, University of Algiers 1. He obtained his Ph.D in Endocrine and Metabolic Physiology and Pathophysiology (February, 2016) at Faculty of Biological Sciences. Department of Biology and Physiology of Organisms. University of Sciences and Technology Houari Boumedienne. The abovementioned has worked in the field of animal physiology and nutrition for the last 7 years. He participated as researcher in multiple national projects. The area of his scientific and research specialization include the pathogenesis of diabetes-related microvascular and macrovascular complications such as diabetic nephropathy, diabetic retinopathy and atherosclerosis, histopathological and ultrastructural changes in diabetic Rat, steatosis and steatohépatitis and the use of microparticles as modulators and biomarkers of diabetes and obesity complications. Also, he participated as lecturer or one of the authors in multiple international congresses and seminars and is author of 2 original scientific papers amongst other publications. He currently works as researcher on two projects: Nutritional modulation of microparticles in dyslipidemia and effects of high calorie diet on the development of ultrastructural changes in the arteries.